| 唐量,孙丽君,尹冠军,郭建中.低强度脉冲超声的骨骼肌修复效应及生物学机制研究*[J].,2018,37(1):121-128 |
| 低强度脉冲超声的骨骼肌修复效应及生物学机制研究* |
| Investigation on repair effects and biological mechanism of low intensity pulsed ultrasound on skeletal muscles |
| 投稿时间：2017-10-23 修订日期：2017-12-28 |
| 中文摘要: |
| 骨骼肌是保持人体姿态和运动机能的重要组织器官。大量研究采用低强度脉冲超声（LIPUS）治疗骨折、骨不连、肌腱和韧带损伤等并取得了较好的效果。然而应用LIPUS进行肌肉相关疾病治疗的研究相对较少，详细的机制仍不确定。本文综合相关研究报道，介绍了应用LIPUS进行肌肉修复的生物效应和细胞、肌细胞因子和细胞内信号转导通路的超声作用机制的研究现状。对现有研究存在的问题作了分析，并对肌肉组织损伤的超声治疗和对抗的研究方向进行了展望。 |
| 英文摘要: |
| Skeletal muscles are important tissues in keeping body posture and motor fuction. There are lots of related researches on treatment of fracture, nonunion, tendon and ligament injury by Low intensity pulsed ultrasound (LIPUS). However, there is relatively few research on the use of LIPUS for the treatment of muscle related diseases, and the research level of the mechanism is also low. In this review, we summarized the available literatures and reviewed the effects of LIPUS on muscle injury, and the mechanisms involved in cellular, cytokine and intracellular signaling pathways. We analyzed the existing problems and provided the outlooks of researches of LIPUS on muscle injury. |
| DOI：10.11684/j.issn.1000-310X.2018.01.018 |
| 中文关键词: 低强度脉冲超声,肌肉,卫星细胞,肌细胞因子,力学信号转导 |
| 英文关键词: Low Intensity Pulsed Ultrasound, Muscle, Satellite Cell, Myocyte Factor, Mechanotransduction |
| 基金项目:国家自然科学基金项目 (11727813, 11574192, 11774213), 陕西师范大学中央高校基本科研业务费专项资金资助 (GK20131009) |
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