文章摘要
桂逢烯,郑 昊,李雁浩,谭坚文,杜永洪.高强度聚焦超声间歇式治疗中焦域温度分布的 仿真研究*[J].,2021,40(3):383-390
高强度聚焦超声间歇式治疗中焦域温度分布的 仿真研究*
Simulation research on temperature distribution in focal region during high intensity focused ultrasound intermittent treatment
投稿时间:2020-08-11  修订日期:2021-04-27
中文摘要:
      探究不同治疗深度、组织类型和治疗模式对高强度聚焦超声(High intensity focused ultrasound, HIFU)焦域温度场的影响。采用有限元法建立HIFU辐照组织的仿真模型,通过Westervelt方程和Pennes生物热传导方程计算HIFU焦域的声场和温度场分布。仿真结果表明:随着治疗深度的增加,焦域内温度逐渐降低,有效温升面积减小;不同组织类型在相同条件下的焦域温度不同,但焦域形状差别不大;单次治疗时间长、治疗时间间隔短的模式焦域温升速率快,有效温升面积区域大。焦域温度是HIFU肿瘤治疗中判断治疗有效性和安全性的重要因素之一,本文通过数值仿真法,实现了预测HIFU间歇式治疗模式下焦域组织温度场分布,有望为制定安全、有效的HIFU术前治疗方案提供理论参考。
英文摘要:
      We explore the effect of different treatment depth, tissue type and treatment mode in HIFU focal temperature field. By using finite element method,the acoustic pressure and temperature in HIFU focal region are calculated by using the Westervelt equation and biological heat transfer equations. The simulation results show that with the increase of treatment depth, the temperature in the focal region decreases gradually, and the effective temperature rising area decreases. Under the same condition, the focal region temperature of different tissue types is different, but the focal region shape is not different. The mode with long single treatment time and short treatment interval has fast focal temperature rise rate and large effective temperature rise area. Focal temperature is one of the important factors to judge the therapeutic effectiveness of HIFU tumor therapy. In this paper, by means of numerical simulation, the distribution of tissue temperature field in the lower focal region of HIFU intermittent treatment mode is predicted, which is expected to provide theoretical reference for the formulation of safe and effective HIFU preoperative treatment scheme.
DOI:10.11684/j.issn.1000-310X.2021.03.009
中文关键词: 高强度聚焦超声  治疗模式  深度  焦域  温度场分布
英文关键词: high intensity focused ultrasound  treatment mode  deep  focal region  temperature field distribution
基金项目:重庆市基础研究与前沿探索专项博士后科学基金项目
作者单位E-mail
桂逢烯 重庆医科大学生物医学工程学院,超声医学工程国家重点实验室。超声医疗国家工程研究中心 316477592@qq.com 
郑 昊 超声医学工程国家重点实验室 重庆医科大学生物医学工程学院  
李雁浩 超声医学工程国家重点实验室 重庆医科大学生物医学工程学院  
谭坚文 超声医学工程国家重点实验室 重庆医科大学生物医学工程学院  
杜永洪 超声医学工程国家重点实验室 重庆医科大学生物医学工程学院  
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