文章摘要
潘婷,孙天宇,张艳秋,张默涵,凌子超,菅喜岐.经颅聚焦超声联合微泡开放血脑屏障的数值仿真研究[J].,2021,40(6):843-855
经颅聚焦超声联合微泡开放血脑屏障的数值仿真研究
Numerical simulation of transcranial focused ultrasound combining microbubble-induced blood-brain barrier opening
投稿时间:2021-04-08  修订日期:2021-11-03
中文摘要:
      近年大鼠等动物实验表明经颅聚焦超声联合微泡技术可无创开放血脑屏障实现药物递送,但在临床治疗时由于人体头颅非均质结构及其高声衰减特性,需优化超声经颅聚焦参数和微泡参数。本文基于人头颅CT数据、82阵元相控换能器和血管建立了三维数值仿真模型,研究超声及微泡参数对机械指数和靶区声发射的影响,评估血脑屏障开放程度及组织损伤的可能性。结果表明,声功率和微泡初始密度增大,机械指数和宽带噪声强度增大;频率增大,稳态空化强度增大;当微泡初始半径大于5μm时,稳态空化显著增强。该研究结果为经颅聚焦超声联合微泡技术诱导可控的BBB开放及安全有效递送治疗药物提供了理论数据和技术参考。
英文摘要:
      In recent years, animal experiments such as rats have shown that the combination of transcranial focused ultrasound and microbubbles enables to non-invasively open the blood-brain barrier for brain-targeted drug delivery. However, due to the nonhomogeneous structure of the human head and its high acoustic attenuation characteristics, it is necessary to optimize the ultrasound transcranial focusing parameters and microbubbles parameters when used in clinical treatment. In this paper, a three-dimensional numerical simulation model is established based on human head CT data, an 82-element phase-controlled transducer and blood vessel to study the effects of ultrasound and microbubbles parameters on mechanical index and acoustic emission of the target area, and to evaluate the degree of the blood-brain barrier opening and the possibility of tissue damage. The results show that the mechanical index and broadband noise intensity increase with the increase of sound power and initial density of microbubbles; the stable cavitation intensity increases with the increase of frequency; when the initial radii of the microbubbles are greater than 5μm, the stable cavitation is significantly enhanced. The results of this study provide theoretical data and technical reference for the induction of controllable blood-brain barrier opening by transcranial focused ultrasound combined with microbubbles and the safe and effective delivery of therapeutic drugs.
DOI:10.11684/j.issn.1000-310X.2021.06.006
中文关键词: 血脑屏障  经颅聚焦超声  微泡  机械指数  声发射
英文关键词: blood-brain barrier  transcranial focused ultrasound  microbubbles  mechanical index  acoustic emission.
基金项目:
作者单位E-mail
潘婷 天津医科大学 13163095669@163.com 
孙天宇 天津医科大学 suntianyu@tmu.edu.cn 
张艳秋 天津医科大学 15620610782@126.com 
张默涵 天津医科大学 momo1612120246@163.com 
凌子超 天津医科大学 18602270251@163.com 
菅喜岐 天津医科大学 jianxiqi@tmu.edu.cn 
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