| 确太降初.生物组织内低频振动声信号特性仿真研究*[J].,2024,43(5):1070-1078 |
| 生物组织内低频振动声信号特性仿真研究* |
| Simulation Study on Characteristics of Low Frequency Vibration Acoustic Signal in Biological Tissue |
| 投稿时间：2023-06-06 修订日期：2024-09-02 |
| 中文摘要: |
| 摘要：振动声成像是一种新兴的超声成像方式，它是通过间接获取生物组织的声学和机械信息进行成像，同时弥补了传统超声医学成像分辨率不足的问题，具有潜在的临床应用价值。然而，目前振动声成像的组织对比度不高，其中一个重要原因是需要进一步明晰不同生物组织内的低频振动声信号特性，因此探究不同组织对低频声振动的敏感度和差异性极具价值。本文基于k-Wave声学仿真平台，通过构建扇形阵列双频聚焦超声的声传播仿真模型，计算并分析了共焦区的声辐射力大小及低频振动声信号的幅值特性。此外，考察了生物组织特性、双频聚焦超声换能器的张角大小、中心频率以及分瓣数对低频振动声信号幅值的影响。仿真研究结果表明：不同生物组织内低频振动声信号的幅值存在差异，与组织参数密不可分。使用大张角聚焦超声换能器可增大共焦区的动态声辐射力，进而提高超声激发声发射（Ultrasound-Stimulated Acoustic Emission, USAE）信号强度。此外，换能器中心频率的选取会影响USAE信号的强度；改变换能器分瓣数N的大小，USAE信号幅值的变化不明显。该研究为明晰不同生物组织内振动声成像的物理机制提供了理论支撑。 |
| 英文摘要: |
| Abstract: Vibroacoustic imaging is a new ultrasonic imaging method, which indirectly obtains the acoustic and mechanical information of biological tissue for imaging, and makes up for the lack of resolution of traditional ultrasonic medical imaging, and has potential clinical application value. However, at present, the tissue contrast of vibrational acoustic imaging is not high, one of the important reasons is that the characteristics of low-frequency vibrational acoustic signals in different biological tissues need to be further clarified. Therefore, it is of great value to explore the sensitivity and difference of different tissues to low-frequency acoustic vibration. In this paper, based on k-Wave acoustic simulation platform, the acoustic propagation simulation model of sector array dual-frequency focused ultrasound is constructed, and the intensity of acoustic radiation in confocal region and the amplitude characteristics of low-frequency vibration acoustic signal are calculated and analyzed. In addition, the effects of the characteristics of biological tissue, the Angle size, center frequency and the number of lobes on the amplitude of the low-frequency acoustic signal were investigated. The simulation results show that the amplitude of low-frequency vibration signals in different biological tissues is different, which is closely related to the tissue parameters. The dynamic acoustic radiation force in the confocal region can be increased by using a large Angle focusing ultrasonic transducer, thus increasing the Ultrasound-Stimulated Acoustic Emission（ USAE）signal intensity. In addition, the selection of the center frequency of the transducer will affect the intensity of USAE signal. The amplitude of USAE signal does not change obviously when the number N of the transducer is changed. This study provides theoretical support for clarifying the physical mechanism of vibration acoustic imaging in different biological tissues. |
| DOI：10.11684/j.issn.1000-310X.2024.05.017 |
| 中文关键词: 双频聚焦超声 振动声成像 低频振动声信号 生物组织 |
| 英文关键词: Dual-frequency focused ultrasound Vibro-Acoustography Low-frequency vibroacoustic signals, Biological tissue |
| 基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目） |
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