| 曹奇,徐阳诚,贺新明,沈灿林,李雁浩.HIFU治疗中换能器驱动电功率变化机制及规律*[J].,2024,43(2):450-460 |
| HIFU治疗中换能器驱动电功率变化机制及规律* |
| The change mechanism and rule of transducer driving electric power in high intensity focused ultrasound therapy |
| 投稿时间：2023-08-17 修订日期：2024-03-04 |
| 中文摘要: |
| 高强度聚焦超声(HIFU)治疗中的驱动电功率对治疗效率起着非常关键的作用,驱动电功率控制的精准性势必会影响治疗的效率和安全性。前期研究表明：HIFU治疗过程中焦域瞬态物理特性的变化会导致换能器的负载阻抗发生变化,进而影响HIFU驱动电功率,但驱动电功率与焦域瞬态物理特性之间的影响关系及规律尚不明确。该文基于电压、电流传感器、空化检测探头和温度传感器等器件,构建了一种HIFU治疗中驱动电功率实时监测及焦域声空化、温度检测系统。基于该实验研究系统,以离体牛心组织作为HIFU辐照对象,分别研究了HIFU焦域温度变化、声空化及组织损伤与驱动电功率之间的变化关系及规律。研究结果表明：当焦域温度升高时,驱动电功率缓慢上升,驱动电功率与温度变化有良好的相关性；当空化产生时,驱动电功率出现明显的波动；当组织出现损伤时,驱动电功率呈陡然下降的变化。三种情景下,驱动电功率变化有明显区别,这有望为区分HIFU治疗过程中焦域处发生损伤和空化以及实时监测靶组织损伤程度提供一种新的解决方案。 |
| 英文摘要: |
| The driving electric power in high-intensity focused ultrasound (HIFU) treatment plays a crucial role in treatment efficiency, and the accuracy of driving electric power control inevitably affect the efficiency and safety of treatment. Previous studies show that changes in the transient physical characteristics of the focal region during HIFU treatment can lead to changes in the load impedance of the transducer, thereby affecting the driving electric power output of HIFU. However, the relationship and pattern between the driving electric power and the transient physical characteristics of the focal region are not yet clear. This article constructs a real-time monitoring system for driving electric power and focal domain acoustic cavitation and temperature detection in HIFU treatment based on devices such as voltage and current sensors, cavitation detection probes, and temperature sensors. Based on this experimental research system, in vitro bovine heart tissue is used as the HIFU irradiation object to study the relationship and rules between the changes in focal region temperature, acoustic cavitation, tissue damage, and driving electric power of HIFU. The research results indicate that as the focal region temperature increases, the driving electric power slowly increases, and there is a good correlation between the driving electric power and temperature changes; When cavitation occurs, there is a significant fluctuation in the driving electric power; when tissue damage occurs, the driving electric power shows a sudden decrease in change. Under the three scenarios, there are significant differences in the changes in driving electric power, which is expected to provide a new solution for distinguishing between damage and cavitation in the focal region during HIFU treatment, as well as real-time monitoring of the degree of target tissue damage. |
| DOI：10.11684/j.issn.1000-310X.2024.02.025 |
| 中文关键词: 高强度聚焦超声 驱动电功率 组织损伤 温度, 声空化 |
| 英文关键词: High intensity focused ultrasound Driving electric power Tissue damage Temperature Acoustic cavitation |
| 基金项目:强脉冲时序调控HIFU焦域空化机制及加速组织热消融研究(12174043) |
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