| 谢慧琳,吴燕琪,王月兵,郭晓安,曹慧媛.聚焦超声治疗下颗粒介质热增效的机理与实验研究*[J].,2025,44(4):867-876 |
| 聚焦超声治疗下颗粒介质热增效的机理与实验研究* |
| Mechanism and experimental study on thermal enhancement of particulate medium under the focused ultrasound therapy |
| 投稿时间：2024-03-06 修订日期：2025-06-25 |
| 中文摘要: |
| 为了提高聚焦超声在肿瘤治疗中的高效性和安全性，该文在保障聚焦超声安全治疗的前提下，研究了颗粒在低功率超声作用下的热增效作用。通过建立流固耦合的两相模型模拟含颗粒的生物组织，考虑介质黏滞性，引入Sewell声衰减模型来描述声场中颗粒由于散射和介质黏滞所引起的声衰减作用，并且基于生物传热方程，计算不同颗粒介质模型的温度响应曲线，研究不同体积分数、粒径参数的影响作用。为了验证理论方法的正确性，开展含颗粒仿生体模的红外测温实验。结果表明，实验与理论结果基本一致，粘弹性介质中颗粒的存在增强了黏滞热效应，使聚焦超声的热累积效率提高了2~3倍，为临床治疗应用奠定了理论基础。 |
| 英文摘要: |
| In order to improve the efficiency and safety of focused ultrasound in tumor treatment, this paper investigates the thermal potentiation of particles on low-power focused ultrasound under the premise of guaranteeing the safe treatment with focused ultrasound. The two-phase model of fluid-solid coupling is used to simulate biological tissues containing particles, and the Sewell acoustic attenuation model is introduced to describe the acoustic attenuation of particles in the acoustic field due to scattering and medium viscosity, considering medium viscosity. Moreover, based on the bioheat transfer equation, the temperature response curves of different particles in the medium model are computed, and the effects of different volume fraction and particle size parameters are investigated. In order to verify the correctness of the theoretical method, infrared temperature measurement experiments of the particle-containing bionic body model are carried out. The results show that the theoretical and experimental results are basically consistent, and the presence of particles in the viscoelastic medium enhances the viscous thermal effect, so that the thermal accumulation efficiency of focused ultrasound is increased by 2-3 times, which lays a theoretical foundation for clinical therapeutic applications. |
| DOI：10.11684/j.issn.1000-310X.2025.04.007 |
| 中文关键词: 聚焦超声 颗粒 热增效 黏滞效应 |
| 英文关键词: Focused ultrasound Particles Thermal enhancement Viscous effect |
| 基金项目:浙江省重点研发计划 (2022C01002)/国家市场监管重点实验室（声学振动精密测量技术）开放基金(AVL202301)/浙江省属高校基本科研业务费专项(2023YW89）/浙江省大学生科研创新活动计划项目（2023R409A051） |
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