Page 57 - 《应用声学》2021年第6期

第 40 卷 第 6 期 潘婷等： 经颅聚焦超声联合微泡开放血脑屏障的数值仿真研究 853

后保持不变趋势。 [6] Lu C T, Zhao Y Z, Wong H L, et al. Current approaches
(3) 随声功率的增大MI > 0.3的区域面积增大， to enhance CNS delivery of drugs across the brain barri-
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2241–2257.
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域面积先减小后几乎保持不变，在微泡初始半径为 term ischemia augments bradykinin-mediated opening of
6 µ m时，MI max 最大。 the blood-tumor barrier in rats with RG2 glioma[J]. Neu-
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(4) 当声功率为 0.5 W 时，次谐波、超谐波强 [8] Jogani V, Jinturkar K, Vyas T, et al. Recent patents
度较大；次谐波和超谐波的强度随频率和微泡初始 review on intranasal administration for CNS drug deliv-
密度增大而增大，当微泡初始半径为 1 ∼ 5 µm 时， ery[J]. Recent Patents on Drug Delivery & Formulation,
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次谐波和超谐波维持在较低水平，当初始半径大于
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5 µm时，次谐波和超谐波强度显著增加。 intensity ultrasound on the central nervous system of the
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声强度增大，超声频率和微泡初始半径的变化对宽
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(1) 微泡可使超声能量集聚，形成次谐波和超
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高时，可能损伤靶区组织。
a demonstration of feasibility and enhanced doxorubicin
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致谢 感谢天津医科大学肿瘤医院提供的志愿者 44(2): E15.
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