Page 47 - 《应用声学》2021年第6期

第 40 卷 第 6 期 Vol. 40, No. 6
2021 年 11 月 Journal of Applied Acoustics November, 2021

⋄ 研究报告 ⋄

经颅聚焦超声联合微泡开放血脑屏障的数值仿真研究

潘 婷 孙天宇 张艳秋 张默涵 凌子超 菅喜岐 †

(天津医科大学生物医学工程与技术学院 天津 300070)

摘要：近年大鼠等动物实验表明经颅聚焦超声联合微泡技术可无创开放血脑屏障实现药物递送，但在临床
治疗时由于人体头颅非均质结构及其高声衰减特性，需优化超声经颅聚焦参数和微泡参数。该文基于人头颅
CT 数据、82 阵元相控换能器和血管建立了三维数值仿真模型，研究超声及微泡参数对机械指数和靶区声发射
的影响，评估血脑屏障开放程度及组织损伤的可能性。结果表明，声功率和微泡初始密度增大，机械指数和
宽带噪声强度增大；频率增大，稳态空化强度增大；当微泡初始半径大于 5 µm 时，稳态空化显著增强。该研
究结果为经颅聚焦超声联合微泡技术诱导可控的血脑屏障开放及安全有效递送治疗药物提供了理论数据和
技术参考。
关键词：血脑屏障；经颅聚焦超声；微泡；机械指数；声发射
中图法分类号: R454.3 文献标识码: A 文章编号: 1000-310X(2021)06-0843-13
DOI: 10.11684/j.issn.1000-310X.2021.06.006

Numerical simulation of transcranial focused ultrasound combining

microbubble-induced blood-brain barrier opening

PAN Ting SUN Tianyu ZHANG Yanqiu ZHANG Mohan LING Zichao JIAN Xiqi

(Department of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin 300070, China)

Abstract: In recent years, animal experiments such as rats have shown that the combination of transcranial
focused ultrasound and microbubbles enables to non-invasively open the blood-brain barrier for brain-targeted
drug delivery. However, due to the nonhomogeneous structure of the human head and its high acoustic
attenuation characteristics, it is necessary to optimize the ultrasound transcranial focusing parameters and
microbubbles parameters when used in clinical treatment. In this paper, a three-dimensional numerical sim-
ulation model is established based on human head CT data, an 82-element phase-controlled transducer and
blood vessel to study the effects of ultrasound and microbubbles parameters on mechanical index and acoustic
emission of the target area, and to evaluate the degree of the blood-brain barrier opening and the possibility
of tissue damage. The results show that the mechanical index and broadband noise intensity increase with
the increase of sound power and initial density of microbubbles; the stable cavitation intensity increases with
the increase of frequency; when the initial radii of the microbubbles are greater than 5 µm, the stable cavi-
tation is significantly enhanced. The results of this study provide theoretical data and technical reference for
the induction of controllable blood-brain barrier opening by transcranial focused ultrasound combined with
microbubbles and the safe and effective delivery of therapeutic drugs.
Keywords: Blood-brain barrier; Transcranial focused ultrasound; Microbubbles; Mechanical index; Acoustic
emission

2021-04-08 收稿; 2021-06-21 定稿
作者简介: 潘婷 (1995– ), 女, 安徽六安人, 硕士研究生, 研究方向: 超声医学。
† 通信作者 E-mail: jianxiqi@tmu.edu.cn