Page 23 - 《应用声学》2022年第5期

第 41 卷 第 5 期 Vol. 41, No. 5
2022 年 9 月 Journal of Applied Acoustics September, 2022

⋄ 研究报告 ⋄

流动微泡群瞬态空化强度时域分布的比例反馈调节 ∗

闫 博 1 谭纯洁 1 胡亚欣 2† 秦 鹏 1†

(1 上海交通大学感知科学与工程学院 上海 200240)
(2 深圳大学生物医学工程学院 深圳 518060)
摘要：声波、血流环境及流动微泡群的稳定性都会影响焦区内瞬态空化强度在超声作用时间内的分布，从而影
响基于瞬态空化的治疗效率和生物安全性。该文在搭建仿体中流动微泡群瞬态空化发生和实时测量系统的基
础上，设计了基于 LabView 现场可编程门阵列的比例反馈控制器，在保持脉冲重复频率和脉冲长度不变的条
件下，通过选择适当的比例系数，依据当前周期的声波激励下实时测量的瞬态空化强度，实时调节下一周期声
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波信号的峰值负压，以调控瞬态空化强度在时间上的分布。研究表明，在最优比例系数 (1 × 10 ) 下，和开环系
统相比，瞬态空化强度的稳定率提升至 2.31 倍，瞬态空化强度的时域下降速率减小约 94.41%；在超声作用时间
内总瞬态空化强度也基本达到期望水平。这些结果表明该比例反馈控制器在调控脉冲超声激励下流动微泡群
瞬态空化强度时域分布的有效性，有望改进瞬态空化在相关疾病治疗中的效率和安全性。
关键词：脉冲超声；瞬态空化；微泡；比例反馈控制
中图法分类号: R312 文献标识码: A 文章编号: 1000-310X(2022)05-0699-11
DOI: 10.11684/j.issn.1000-310X.2022.05.003

Time domain distribution regulation of inertial cavitation intensity of flowing
microbubbles based on proportional feedback controller

YAN Bo 1 TAN Chunjie 1 HU Yaxin 2 QIN Peng 1

(1 School of Perceptual Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China)
(2 School of Biomedical Engineering, Shenzhen University, Shenzhen 518060, China)

Abstract: Acoustic pulse excitation,the blood flow environment and the stability of the microbubbles have
influence on the distribution of inertial cavitation intensity (ICI) within the focal region during the exposure
time, thus affecting the efficacy and biosafety of inertial cavitation-based therapy. Based on a real-time mea-
surement system of inertial cavitation of the flowing microbubbles in tissue-mimicking phantom, a proportional
feedback controller based on LabView field programmable gate array (FPGA) was designed to regulate the
temporal distribution of ICI. Under the condition of maintaining pulse repetition frequency and pulse length
unchanged, via the optimal proportional coefficients, the amplitude of the next acoustic pulse (corresponding to
the peak negative pressure) was real-time regulated by the measured ICI elicited by the present acoustic pulse.
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The results show that when using an optimal proportional coefficient (1 × 10 ), the stability rate of ICI was
increased to about 2.31 times that of open-loop system, the decreasing rate of ICI in time domain was reduced
94.41% of open-loop system, and the total ICI reached the desired level within the ultrasound exposure time.

2021-08-19 收稿; 2021-10-11 定稿
国家自然科学基金项目 (12074255), 上海交通大学医工交叉基金重点项目 (YG2019ZD27)
∗
作者简介: 闫博 (1996– ), 男, 陕西商洛人, 硕士研究生, 研究方向: 超声空化的实时调控。
† 通信作者 E-mail: yxhu@szu.edu.cn; pqin@sjtu.edu.cn