Page 205 - 《应用声学》2023年第2期

第 42 卷 第 2 期 Vol. 42, No. 2
2023 年 3 月 Journal of Applied Acoustics March, 2023

⋄ 研究报告 ⋄

经颅超声刺激人脑海马的数值仿真研究 ∗

张默涵 1 张艳秋 1 凌子超 1 王佩国 2 菅喜岐 1†

(1 天津医科大学生物医学工程与技术学院 天津 300070)
(2 天津医科大学肿瘤医院放疗科 天津 300070)
摘要：颞叶癫痫、阿尔兹海默症等神经系统疾病与大脑海马的异常放电相关。近年兴起的经颅超声刺激治疗
脑疾病具有无创、能深入脑组织和可调控海马神经元放电的特点。该文基于 128 阵元相控阵换能器、人头颅
CT 数据、水体建立超声经颅刺激海马数值仿真模型，数值仿真优选适应于海马刺激的换能器结构参数，并结
合电容模型，探究超声声学参数对海马神经元放电的影响。结果表明曲率半径 90 mm、开口半径 56 mm、阵元
半径 2.0 mm、频率 0.9 MHz 的 128 阵元相控超声换能器可形成适应于刺激人脑海马大小的焦域；且在超声频
率为 0.9 MHz 时对海马神经元放电有较好的抑制作用；在较小的占空比和较低的空间峰值时间平均声强条件
下对神经元放电有较好的抑制作用。
关键词：经颅超声刺激；神经刺激；相控阵换能器；超声参数；海马
中图法分类号: R454.3 文献标识码: A 文章编号: 1000-310X(2023)02-0393-13
DOI: 10.11684/j.issn.1000-310X.2023.02.024

Transcranial ultrasound stimulation of the human hippocampus: a numerical
simulation study

ZHANG Mohan 1 ZHANG Yanqiu 1 LING Zichao 1 WANG Peiguo 2 JIAN Xiqi 1

(1 Department of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin 300070, China)
(2 Department of Radiotherapy, Cancer Institute and Hospital of Tianjin Medical University, Tianjin 300070, China)

Abstract: Neurological diseases such as Temporal lobe epilepsy, Alzheimer’s disease are associated with ab-
normal discharges in the hippocampus of the brain. Transcranial ultrasound stimulation, which has emerged
in recent years to treat brain diseases, is non-invasive, penetrates deep into brain tissue and can modulate hip-
pocampal neuronal firing. In this paper, a numerical simulation model of ultrasonic transcranial stimulation of
hippocampus was established based on the 128-element phase-controlled transducer, human head CT data and
water. Numerical simulations were performed to optimize the structural parameters of the transducer adapted
to the stimulation of the hippocampal region, then combined with the capacitance model to investigate the
effects of ultrasonic acoustic parameters on the firing of hippocampal neurons. The results showed that a 128-
element phase-controlled transducer with a radius of curvature of 90 mm, an opening radius of 56 mm, an array
radius of 2.0 mm, and a frequency of 0.9 MHz could form a focal field adapted to the size of the stimulated
hippocampus of the human brain; and the ultrasound frequency of 0.9 MHz showed a better inhibition effect
on hippocampal neuronal discharge. A smaller duty cycle and lower spatial peak temporal average intensity
showed a better inhibition effect on neuron discharge.
Keywords: Transcranial ultrasound stimulation; Neuron stimulation; Phase-controlled transducer; Ultrasound
parameters; Hippocampus
2021-12-20 收稿; 2022-02-16 定稿
天津市自然科学基金项目 (16JC2DJC32200)
∗
作者简介: 张默涵 (1997– ), 女, 安徽安庆人, 硕士研究生, 研究方向: 超声医学。
† 通信作者 E-mail: jianxiqi@tmu.edu.cn