Page 117 - 《应用声学》2025年第1期

第 44 卷 第 1 期 Vol. 44, No. 1
2025 年 1 月 Journal of Applied Acoustics January, 2025

⋄ 研究论文 ⋄

基于环阵超声的高精度微量移液平台 ∗

张 扬 1,3 黄友塔 2,3 王 彦 1 张志强 3 于妍妍 2 邱维宝 3†

(1 南华大学电气工程学院 衡阳 421001)
(2 深圳大学医学部生物医学工程学院 深圳 518060)
(3 中国科学院深圳先进技术研究院 生物医学与健康工程研究所 保罗·C·劳特伯生物医学成像研究中心 深圳 518055)
摘要：非接触式超声移液技术在药物开发、合成生物学、分子诊断等生物医学领域具有广阔的应用潜力。目前
基于单阵元聚焦换能器的超声移液技术，因换能器制作工艺简单及能量大等优势得到了广泛的应用。然而基
于单阵元换能器的超声移液方式因为换能器焦距固定需要机械移动换能器实现不同高度液体的转移，导致移
液效率较低、通量低。环阵换能器可以采用电子聚焦的方式实现焦点在轴向上动态调节，能够克服单阵元换能
器焦距固定的缺点，有望提高超声移液效率。因此，该文自主设计并制作了基于现场可编程门阵列 (FPGA) 的
五通道高精度超声信号发射系统，采用定制的五阵元环阵超声换能器搭建了一套基于环阵超声的高精度超声
移液平台。该移液平台可以实现超声焦点动态精准调节，并在不同焦距情况下实现纳升级液滴精准转移，可以
有效提高超声移液效率和通量，具有重要的应用价值和前景。
关键词：电子聚焦；环阵超声换能器；FPGA；超声移液
中图法分类号: TM931 文献标识码: A 文章编号: 1000-310X(2025)01-0113-07
DOI: 10.11684/j.issn.1000-310X.2025.01.011

An annular array based platform for high-precision low-volume acoustic

liquid transfer

ZHANG Yang 1,3 , HUANG Youta 2,3 , WANG Yan , ZHANG Zhiqiang ,
1
3
2
YU Yanyan and QIU Weibao 3
(1 University of South China, College of Electrical Engineering, Hengyang 421001, China)
(2 School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, China)
(3 Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering,
Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China)

Abstract: Non-contact ultrasonic liquid handling technology has great potential applications in biomedical
fields such as drug development, synthetic biology, and molecular diagnostics. Currently, single-element
focused transducer has been widely used in the ultrasonic liquid handling technology due to its advantages of
simple fabrication process and high energy output. However, the single-element transducer-based ultrasonic
liquid handling method requires mechanical movement of the transducer to achieve transfer of liquids at differ-
ent heights due to the fixed focal length of the transducer, resulting in low efficiency and low throughput. An
annular array transducer can dynamically adjust the focus along the axial direction using electronic focusing,
which overcomes the drawback of the fixed focal length of single-element transducer and is expected to improve
the efficiency of ultrasonic liquid handling. Therefore, in this study, we designed and fabricated a five-channel

2023-09-22 收稿; 2023-11-10 定稿
国家重点研发计划项目 (2018YFA0902900)
∗
作者简介: 张扬 (1998– ), 女, 陕西安康人, 硕士研究生, 研究方向: 信息与通信工程。
† 通信作者 E-mail: wb.qiu@siat.ac.cn