Page 22 - 《应用声学》2022年第4期
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第 41 卷 第 4 期                                                                       Vol. 41, No. 4
             2022 年 7 月                          Journal of Applied Acoustics                      July, 2022

             ⋄ 研究报告 ⋄



                                超声激发声信号幅值实时监测


                                        HIFU焦域组织损伤                             ∗



                          田 丽    1   郑 昊     1   谢 伟    1   李发琪     1   王智彪      1,2  李雁浩      1†


                                (1  重庆医科大学超声医学工程国家重点实验室、生物医学工程学院                重庆   400016)
                                            (2  超声医疗国家工程研究中心        重庆   401121)

                摘要：聚焦超声消融肿瘤过程中的损伤实时监测是临床治疗面临的一个关键难题，双频聚焦超声不仅能提高
                治疗效率，且能在共焦区域激发出声信号，该声信号的幅值、频率等信息与焦域组织的机械和声学特性紧密相
                关。该文构建了一种双频聚焦超声治疗及组织损伤实时监测系统。该系统在聚焦超声辐照离体组织过程中，
                通过外部水听器接收双频激发的组织声发射信号，并通过上位机进行高速数据采集、数字滤波、时频处理等，
                分析声发射信号幅值与离体组织损伤之间的变化规律。实验研究结果表明：随着焦域组织损伤的形成，其弹性
                等声学特征发生改变，导致声发射信号幅值逐渐降低，表明声发射信号幅值的变化可较好地反映靶组织声学
                特征和结构的变化，从而实现聚焦超声治疗中靶组织损伤的实时监测。该文提出的监测方案相比传统超声影
                像监控更灵敏，有望为聚焦超声临床治疗中的组织损伤监控提供一种新的实时监测方案和手段。
                关键词：聚焦超声；双频超声换能器；声发射信号；实时监测
                中图法分类号: O429           文献标识码: A          文章编号: 1000-310X(2022)04-0520-07
                DOI: 10.11684/j.issn.1000-310X.2022.04.003

                 Real time monitoring of tissue damage in HIFU focal region by ultrasonic

                                        excitation acoustic signal amplitude


                       TIAN Li 1  ZHENG Hao   1  XIE Wei 1  LI Faqi 1  WANG Zhibiao 1,2  LI Yanhao 1

              (1 State Key Laboratory of Ultrasonic Medical Engineering, Chongqing Medical University College of Biomedical Engineering,
                                                   Chongqing 400016, China)
                          (2 National Engineering Research Center of Ultrasound Medicine, Chongqing 401121, China)

                 Abstract: Real time damage monitoring in the process of focused ultrasound ablation is a key problem in
                 clinical treatment. Dual frequency focused ultrasound can not only improve the treatment efficiency, but also
                 stimulate the acoustic signal in the confocal region. The amplitude and frequency of the acoustic signal are
                 closely related to the mechanical and acoustic characteristics of the focal region tissue. In this paper, a dual
                 frequency focused ultrasound treatment and tissue damage real-time monitoring system is constructed. During
                 the process of focused ultrasound irradiating the tissue in vitro, the system receives the tissue acoustic emission
                 signal excited by dual frequency through the external hydrophone, and carries out high-speed data acquisition,
                 digital filtering, time-frequency processing and so on through the upper computer to analyze the change law
                 between the amplitude of acoustic emission signal and the tissue damage in vitro. The experimental results


             2021-06-21 收稿; 2021-08-13 定稿
             重庆市基础研究与前沿探索专项博士后科学基金目 (cstc2019jcyj-bshX0075)
             ∗
             作者简介: 田丽 (1996– ), 女, 重庆人, 硕士研究生, 研究方向: 高强度聚焦超声治疗与监控。
             † 通信作者 E-mail: liyanhao@cqmu.edu.cn
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