Page 65 - 《应用声学》2021年第3期

第 40 卷 第 3 期 Vol. 40, No. 3
2021 年 5 月 Journal of Applied Acoustics May, 2021

⋄ 研究报告 ⋄

高强度聚焦超声间歇式治疗中焦域温度分布的

仿真研究 ∗

桂逢烯 1 郑 昊 1 李雁浩 1† 谭坚文 1,2 杜永洪 1

(1 超声医学工程国家重点实验室 重庆医科大学生物医学工程学院 重庆 400016)

(2 超声医疗国家工程研究中心 重庆 401121)
摘要：探究不同治疗深度、组织类型和治疗模式对高强度聚焦超声焦域温度场的影响。采用有限元法建立高
强度聚焦超声辐照组织的二维轴对称仿真模型，通过 Westervelt 方程和 Pennes 生物热传导方程计算高强度聚
焦超声焦域的声场和温度场分布。仿真结果表明：随着治疗深度的增加，焦域内温度逐渐降低，有效温升面积
减小；不同组织类型在相同条件下的焦域温度不同，但焦域形状差别不大；单次治疗时间长、治疗时间间隔短
的模式焦域温升速率快，有效温升面积区域大。焦域温度是高强度聚焦超声肿瘤治疗中判断治疗有效性和安
全性的重要因素之一，该文通过数值仿真法，实现了预测高强度聚焦超声间歇式治疗模式下焦域组织温度场
分布，有望为制定安全、有效的高强度聚焦超声术前治疗方案提供理论参考。
关键词：高强度聚焦超声；治疗模式；深度；焦域；温度场分布
中图法分类号: R318 文献标识码: A 文章编号: 1000-310X(2021)03-0383-08
DOI: 10.11684/j.issn.1000-310X.2021.03.009

Simulation research on temperature distribution in focal region during

high intensity focused ultrasound intermittent treatment

GUI Fengxi 1 ZHENG Hao 1 LI Yanhao 1 TAN Jianwen 1,2 DU Yonghong 1
(1 State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering,
Chongqing Medical University, Chongqing 400016, China)
(2 National Engineering Research Center of Ultrasound Medicine, Chongqing 401121, China)

Abstract: The effect of different treatment depth, tissue type and treatment mode in high intensity focused
ultrasound (HIFU) focal temperature field is explored in this paper. A two-dimensional axisymmetric simula-
tion model of HIFU irradiated tissue is established by finite element method, then the acoustic pressure and
temperature in HIFU focal region are calculated by using the Westervelt equation and biological heat transfer
equations. The simulation results show that with the increase of treatment depth, the temperature in the focal
region decreases gradually, and the effective temperature rising area decreases. Under the same condition, the
focal region temperature of different tissue types is different, but the focal region shape is not different. The
mode with long single treatment time and short treatment interval has fast focal temperature rise rate and
large effective temperature rise area. Focal temperature is one of the important factors to judge the therapeutic
effectiveness of HIFU tumor therapy. In this paper, by means of numerical simulation, the distribution of tissue

2020-08-11 收稿; 2021-01-24 定稿
重庆市基础研究与前沿探索专项博士后科学基金项目 (cstc2019jcyj-bshX0075)
∗
作者简介: 桂逢烯 (1994– ), 男, 四川人, 硕士研究生, 研究方向: 超声医学, HIFU 热效应。
† 通信作者 E-mail: 1003434421@qq.com